Effects of Nine Active Ingredients in Chinese Herbal Medicine Sho-saiko-to on 2-(2-Furyl)-3-(5-nitro-2-furyl)acryIamide Mutagenicity
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چکیده
منابع مشابه
Statistical analysis on toxicity of a nitrofuran derivative, 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide.
A food additive, furylfuramide or AF-2, which had been used in Japan since 1965 and structurally is composed of 5-nitro-2-furyl radical and acrylamide, was re-examined mainly on chronic toxicity by statistically reviewing published data. The conclusions are as follows: 1) The maximum safety dosage which shows no demonstrable change in rats must be corrected at least to 1/170 of the value which ...
متن کاملFuran derivatives. ЬХХП. Synthesis and some properties of l-(5-nitro-2-furyl)- -2- (5-aryl-2-furyl)ethylenes
Wittig reaction has recently been applied also in the preparation of 5-nitrofuran derivatives of ethylene [1—5]. The quoted syntheses were accomplished starting either from 5-nitrofurfuryl halides which were converted into 5-nitrofurfurylidenephosphoranes and subsequent condensation of the latter with carbonyl compounds [1—4], or the intermediate phosphoranes were prepared from other furfuryl h...
متن کاملRelationships between the carcinogenic and mutagenic or DNA-modifying effects of nitrofuran derivatives, including 2-(2-furyl)-3-(5-nitro-2-furyl)acrylamide, a food additive.
of the 27 nitrofuran derivatives tested had mutagenic effects on E. coli, but none of them had mutagenic effects on S. typhimurium. Twenty-five compounds had DNA-modifying effects on E. coli, and 24 compounds had effects on the DNA of S. typhimurium. Fifteen of the 27 compounds are known to be carcinogenic. Fourteen of these 15 carcinogenic derivatives had mutagenic effects on E. coli and DNA-m...
متن کاملAntiprotozoal thiazoles. 2. 2-(5-Nitro-2-furyl-, thiazolyl-, and 1-methylimidazolyl-)thiazoles.
Ten 2-substituted 4-thiazolecarboxaldehyde hydrazones bearing 5-nitro-2-furyl, 5-nitro-2-thiazolyl, and 1-methyl-5-nitro-2-imidazolyl functions have been prepared and screened for activity against Trypanosoma cruzi infections in mice. The results permitted the ranking of these substituents in decreasing order of activity: 1-methyl-5-nitro-2-imidazolyl greater than 5-nitro-2-furyl greater than 5...
متن کاملCarcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl] acetamide in female rats.
Dawley male and female rats (3 , 5 , 6). As NFTA4 (Chart 1) differs from N-[4-5-nitro-2-furyl)-2-thiazolylj formamide only in that the acetyl group replaces the formyl group; and because NFTA is currently being used as an antibiotic in the therapy of human infectious disease, it seemed imperative that NFTA be studied for chronic toxicity and possible carcinogenicity.
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ژورنال
عنوان ژورنال: Japanese Journal of Cancer Research
سال: 1995
ISSN: 0910-5050
DOI: 10.1111/j.1349-7006.1995.tb03305.x